Levothyroxine replacement in primary congenital hypothyroidism: the higher the initial dose the higher the rate of overtreatment
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, vol.29, no.2, pp.133-138, 2016 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 29 Issue: 2
- Publication Date: 2016
- Doi Number: 10.1515/jpem-2015-0047
- Journal Name: JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.133-138
- Keywords: congenital hypothyroidism, L-thyroxine, overtreatment
- Dokuz Eylül University Affiliated: Yes
Abstract
Background: Congenital hypothyroidism (CH) is the most frequent endocrine disorder during the neonatal period, and a delay in diagnosis and treatment leads to irreversible complications. A high L-thyroxine (LT4) dose is recommended for treatment, while the optimal starting dose is still a matter of debate. The objective of this study was to determine the effects of various starting doses of LT4 on serum thyroid stimulating hormone (TSH) and thyroxine (fT4) at the end of the first month of treatment.