Levothyroxine replacement in primary congenital hypothyroidism: the higher the initial dose the higher the rate of overtreatment

Tuhan H., ABACI A., Cicek G., Anik A., Catli G., DEMİR K., ...Daha Fazla

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, cilt.29, sa.2, ss.133-138, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 2
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1515/jpem-2015-0047
  • Dergi Adı: JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.133-138
  • Anahtar Kelimeler: congenital hypothyroidism, L-thyroxine, overtreatment, L-THYROXINE, CHILDREN, THERAPY, GROWTH
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background: Congenital hypothyroidism (CH) is the most frequent endocrine disorder during the neonatal period, and a delay in diagnosis and treatment leads to irreversible complications. A high L-thyroxine (LT4) dose is recommended for treatment, while the optimal starting dose is still a matter of debate. The objective of this study was to determine the effects of various starting doses of LT4 on serum thyroid stimulating hormone (TSH) and thyroxine (fT4) at the end of the first month of treatment.