Lipid peroxidation and antioxidant status in stomach cancer

BATÇIOĞLU K., Mehmet N., Ozturk I., YILMAZ M. B., AYDOĞDU N., Erguvan R., ...Daha Fazla

CANCER INVESTIGATION, cilt.24, sa.1, ss.18-21, 2006 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 1
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1080/07357900500449603
  • Dergi Adı: CANCER INVESTIGATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.18-21
  • Anahtar Kelimeler: stomach cancer, antioxidant system, oxidative damage, lipid peroxidation, free radical
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Background: Considerable evidences have linked oxidative damage and cancer. In this article, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSHPx) activities, and malondialdehyde (MDA) and nitric oxide metabolites' levels (NOx) were investigated in patients with stomach cancer. Methods: All measurments were done by spectrophotometric techniques. Results: We observed a significant decrease in the activities of SOD and CAT in tumour tissues when compared with control tissues. The different of GSHPx activities and NO metabolite' levels were not statistically significant. MDA levels were significantly increased. Conclusions: We conclude that increased MDA levels and decreased antioxidant enzyme activities can be valuable parameters in assessing the possible risk of cancer.