Akademik Veri Yönetim Sistemi
Conference on Photonic Therapeutics and Diagnostics IX, San-Francisco, Kostarika, 2 - 07 Şubat 2013, cilt.8565
Optical nerve stimulation (ONS) is being explored for identification and preservation of the cavernous nerves (CN), responsible for erectile function, during prostate cancer surgery. This study compares three pulsed infrared lasers to determine whether differences in spectral linewidth and/or temporal pulse profile influence successful ONS of CN. Infrared laser radiation from the Capella diode laser (1873 nm, 5 ms, 10 Hz), Thulium fiber laser (TFL) (1873 nm, 5 ms, 10 Hz), and solid-state Holmium: YAG laser (2120 nm, 200 mu s, 5 Hz) were transmitted through 400-mu m-core-diameter optical fibers, producing a 1-mm-diameter-spot on the nerve surface. Successful ONS was judged by an intracavernous pressure (ICP) response in the penis (n = 10 rats) during a total stimulation time of 30 s. The narrow linewidth TFL (Delta lambda similar to 0.5 nm) and broad linewidth Capella laser (Delta lambda similar to 12 nm) performed similarly, producing ICP responses with a threshold radiant exposure of similar to 0.45 J/cm(2), and ICP response times of 12-17 s, while the Holmium laser stimulated at similar to 0.59 J/cm(2), and ICP response times of about 14-28 s. All three lasers demonstrated successful ONS of CN. ICP response time was dependent on the rate of energy deposition into the CN, rather than linewidth or temporal pulse profile.