Akademik Veri Yönetim Sistemi
61st Annual ESPE (ESPE 2023), The Hague, Hollanda, 21 - 23 Eylül 2023, ss.95
Introduction-Aim: In cases with early puberty, neuroendocrine,
physical, and psychological changes are considered to result
in several mood disorders. The aim of this research was to assess
the mental problems of pubertal girls with rapidly progressive
puberty (RPP) with menarche before the 10 years of age. To the
best of our knowledge, there is no similar prospective cross-sectional
research in the medical literature.
Method: In this prospective study, females with RPP (breast
developmental Tanner stage ≥ 3 and basal LH value >0.3 IU/L)
who presented with menarche under the age of 10 years were
included in Group I. The control group (Group II) consisted of
prepubertal girls aged 9 to 10 years. All cases were evaluated concurrently
at the Department of Child and Adolescent Mental
Health and Diseases. Cases with a previous diagnosis of mood disorder
or psychiatric treatment for any reason or chronic diseases
were excluded. All subjects underwent relevant psychiatric tests: 1)
Affective Disorders and Schizophrenia Form-Now And Lifelong
Form DSM-5- Turkish version (CDSG-PL-DSM-5-T), 2) Screen
for Child Anxiety Related Disorders (SCARED), 3) Child Behavior
Checklist (CBCL/6-18), and 4) the revised form of a Depression
Rating Scale for children (CDRS-R).
Results: A total of 49 girls (Group I, n=28; Group II, n=21) were
included in the study. Height, weight, and BMI SDS values were
significantly higher in Group I (p<0,01) while target height was
similar among groups. Predicted adult height was higher than target
height in Group I. Mood disorder was detected in four cases:
Group I (n=2, 7%, social phobia-depression/adjustment disorder
with depressive symptoms) and Group II (n=2, 9.0%, childhood
depression). There was no significant difference between the two
groups in terms of the total and sub-group scores obtained from
anxiety, behavior, and depression assessment criteria.
Conclusion: There was no significant difference in the prevalence
of mood disorders between the early menarche and control
groups. GnRH analogue therapy should not be based on the
assumption that premature pubertal development will cause psychosocial
effects and should only be considered after a thorough
psychiatric evaluation.