Psychosocial Evaluation of Girls with Rapidly Progressive Puberty Presenting with Early Menarche


Yüksek Acinikli K., Besci Ö., Akın Kağızmanlı G., Gündoğan N., Unutmaz G., Esen A. B., ...Daha Fazla

61st Annual ESPE (ESPE 2023), The Hague, Hollanda, 21 - 23 Eylül 2023, ss.95

  • Yayın Türü: Bildiri / Özet Bildiri
  • Basıldığı Şehir: The Hague
  • Basıldığı Ülke: Hollanda
  • Sayfa Sayıları: ss.95
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Introduction-Aim: In cases with early puberty, neuroendocrine,

physical, and psychological changes are considered to result

in several mood disorders. The aim of this research was to assess

the mental problems of pubertal girls with rapidly progressive

puberty (RPP) with menarche before the 10 years of age. To the

best of our knowledge, there is no similar prospective cross-sectional

research in the medical literature.

Method: In this prospective study, females with RPP (breast

developmental Tanner stage ≥ 3 and basal LH value >0.3 IU/L)

who presented with menarche under the age of 10 years were

included in Group I. The control group (Group II) consisted of

prepubertal girls aged 9 to 10 years. All cases were evaluated concurrently

at the Department of Child and Adolescent Mental

Health and Diseases. Cases with a previous diagnosis of mood disorder

or psychiatric treatment for any reason or chronic diseases

were excluded. All subjects underwent relevant psychiatric tests: 1)

Affective Disorders and Schizophrenia Form-Now And Lifelong

Form DSM-5- Turkish version (CDSG-PL-DSM-5-T), 2) Screen

for Child Anxiety Related Disorders (SCARED), 3) Child Behavior

Checklist (CBCL/6-18), and 4) the revised form of a Depression

Rating Scale for children (CDRS-R).

Results: A total of 49 girls (Group I, n=28; Group II, n=21) were

included in the study. Height, weight, and BMI SDS values were

significantly higher in Group I (p<0,01) while target height was

similar among groups. Predicted adult height was higher than target

height in Group I. Mood disorder was detected in four cases:

Group I (n=2, 7%, social phobia-depression/adjustment disorder

with depressive symptoms) and Group II (n=2, 9.0%, childhood

depression). There was no significant difference between the two

groups in terms of the total and sub-group scores obtained from

anxiety, behavior, and depression assessment criteria.

Conclusion: There was no significant difference in the prevalence

of mood disorders between the early menarche and control

groups. GnRH analogue therapy should not be based on the

assumption that premature pubertal development will cause psychosocial

effects and should only be considered after a thorough

psychiatric evaluation.