A New Synthetic Framework for 11-Demethylellipticine


Gocmenturk M., GÜNDOĞDU HIZLIATEŞ C., Ergun Y.

JOURNAL OF HETEROCYCLIC CHEMISTRY, cilt.53, sa.3, ss.767-770, 2016 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 53 Sayı: 3
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1002/jhet.2366
  • Dergi Adı: JOURNAL OF HETEROCYCLIC CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.767-770
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

A new synthetic route for the synthesis of 5-methyl-6H-pyrido[4,3-b]carbazole (8), so-called 11-demethylellipticine, was described. Construction of the tetracyclic structure hexahydro-1H-pyrido[4,3-b]carbazol-5(6H)-one skeleton (6) was also achieved by nucleophilic substitution reaction in the synthetic route. Also new tetrahydrocarbazole derivatives (2, 3, 4, and 5) were synthesized. Several ellipticine analogs and octahydropyridocarbazole-based G-protein coupled receptors inhibitors can also be synthesized from tetracyclic structure (6) because of carbonyl functionality at position 5.