Pretreatment with nebivolol attenuates level and expression of matrix metalloproteinases in a rat model of renal ischaemia-reperfusion injury

Ersan S., Tanrisev M., Çavdar Z., Çelik A., Unlu M., Kocak A., ...More

NEPHROLOGY, vol.22, no.12, pp.1023-1029, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 12
  • Publication Date: 2017
  • Doi Number: 10.1111/nep.13007
  • Journal Name: NEPHROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1023-1029
  • Keywords: acute tubular necrosis, acute kidney injury, ischaemia reperfusion, matrix metalloproteinases, nebivolol, CEREBRAL ISCHEMIA/REPERFUSION, ANTIOXIDANT, INHIBITION, BETA
  • Dokuz Eylül University Affiliated: Yes

Abstract

AimMatrix metalloproteinases (MMPs) are zinc-containing proteinases that are involved in the degradation of extracellular matrix (ECM) and a number of cell surface proteins in order to maintain tissue homeostasis. They are involved in pathogenesis of several ischaemic organ injuries. In the present study, we aimed to determine the expression and level of MMP-2 and MMP-9 in renal ischaemia-reperfusion injury (IRI) model and the potential beneficial effect of nebivolol, a (1)-adrenergic receptor blocker, on both MMP-2 and -9 level and expression and tubular injury caused by IRI.