Analysis of apoptotic, platelet-derived, endothelial-derived, and tissue factor-positive microparticles of children with acute lymphoblastic leukemia during induction therapy.

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Yenigurbuz F. D., Kizmazoglu D., Ateş H., Erdem M., Tüfekçi Ö., Yılmaz Ş., ...More

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, vol.30, no.4, pp.149-155, 2019 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 30 Issue: 4
• Publication Date: 2019
• Doi Number: 10.1097/mbc.0000000000000811
• Journal Name: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.149-155
• Keywords: acute lymphoblastic leukemia, childhood, microparticles, thromboembolism, CIRCULATING MICROPARTICLES, THROMBOSIS, CANCER, PREVALENCE, ACTIVATION, DISEASE, EVENTS, CELLS
• Dokuz Eylül University Affiliated: Yes

Abstract

Objectives Thromboembolism is one of the most common complications during induction therapy of pediatric acute lymphoblastic leukemia (ALL). Procoagulant microparticles in the circulation may cause thromboembolic events. The aim of our study was to determine the levels of apoptotic, platelet-derived, endothelial-derived, and tissue factor-positive microparticles of children with ALL at diagnosis and during induction therapy.