Akademik Veri Yönetim Sistemi
CYPRUS JOURNAL OF MEDICAL SCIENCES, cilt.8, sa.6, ss.435-440, 2023 (ESCI)
BACKGROUND/AIMS: The Lymph node staging system provides significant information for laryngeal squamous cell carcinoma (LSCC) prognosis. Additional parameters are suggested in order to improve the prognostic capacity of lymph node staging. This study aimed to investigate the prognostic value of different lymph node staging methods. MATERIALS AND METHODS: The long-term survival data and pathological features of fifty-two patients with LSCC were obtained retrospectively. The effects of metastatic lymph node count (MLNC), metastatic lymph node ratio (MLNR), and the logarithmic ratio of positive lymph nodes (LODDS) on disease-free survival (DFS), disease-specific survival, and overall survival (OS) were analyzed. Significant cut-off values for MLNR and LODDS were calculated using receiver operating characteristic analysis. In addition, Kaplan-Meier survival analysis with log-rank was used for comparisons of nodal disease-related study groups. RESULTS: Cancer recurrence was similar between the groups by T-stage (0.963), N-stage (0.935), MLNR groups (0.297), and LODSS groups (0.244). However, the recurrence rate was significantly lower in tumors with a severe lymphoid response (0.004) and with a total dissected number of lymph nodes >= 18 (0.037). Total lymph node count (0.303), total MLNC (0.768), MNLR (0.656), and LODDS (0.356) values were similar in those patients with and those without cancer recurrence (p>0.05). No significant cut-off value was detected for either DFS or OS for MLNR or LODDS values (p=0.672, area under the curve (AUC): 0.672, 95% confidence interval (CI): 0.365-0.706; p=0.352, AUC: 0.578, 95% CI: 0.411-0.746; p=0.450, AUC: 0.615, 95% CI: 0.222-1; p=0.450, AUC: 0.615, 95% CI: 0.230-0.999, respectively). CONCLUSION: MLNR and LODDS were significant in improving the prognostic value of TNM staging in LSSC.