A Case of Familial Mediterranean Fever Having Intermittent Leukopenia


Beyitler I., KAVUKÇU S.

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, vol.40, no.2, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 2
  • Publication Date: 2018
  • Doi Number: 10.1097/mph.0000000000001055
  • Journal Name: JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: familial mediterranean fever, leukopenia, neutropenia, amyloidosis, NEUTROPENIA
  • Dokuz Eylül University Affiliated: Yes

Abstract

Familial Mediterranean fever (FMF) is a genetically inherited autoinflammatory disorder characterized by inflammatory attacks and may result in amyloidosis as a severe complication. Elevation of acute phase reactants, including leukocytosis, is seen during attack periods. Here we describe a 13-year-old female patient with a very rare clinical presentation of FMF, who would experience FMF attacks when she did not regularly take her colchicine. During these attacks she had leukopenia and neutropenia instead of leukocytosis. The leukocyte count returned to normal when she continued the medication and avoided attacks. Ethnicity and clinical signs are important in leukopenic patientsand should be investigated for FMF to avoid unnecessary procedures and complications.