Effective treatment of hereditary angioedema with fresh frozen plasma in an emergency department.

PEKDEMİR M., ERSEL M., Aksay E., YANTURALI S., Akturk A., Kiyan S.

The Journal of emergency medicine, vol.33, no.2, pp.137-9, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 2
  • Publication Date: 2007
  • Doi Number: 10.1016/j.jemermed.2007.02.024
  • Journal Name: The Journal of emergency medicine
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.137-9
  • Keywords: hereditary angioedema, fresh frozen plasma, emergency department, C1 INHIBITOR DEFICIENCY
  • Dokuz Eylül University Affiliated: Yes

Abstract

Hereditary angioedema (HAE) is a rarely seen disorder of C1 inhibitor (C1-INH) deficiency usually manifested by non-pruritic swelling of the skin. Acute exacerbations are not sensitive to conventional medications, and Cl-esterase inhibitor concentrates are recommended as the first-line therapy. However, fresh frozen plasma is the main treatment alternative in many centers due to the lack of C1-esterase inhibitor concentrates. In this report, we present 3 patients with acute exacerbations of hereditary angioedema who were effectively and safely treated with fresh frozen plasma. (C) 2007 Elsevier Inc.