Atopy patch test in children with cow's milk and hen's egg allergy: Do clinical symptoms matter?

Kose S. S., Asilsoy S., Tezcan D., Atakul G., AL S., Atay Ö., ...More

ALLERGOLOGIA ET IMMUNOPATHOLOGIA, vol.48, no.4, pp.323-331, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 48 Issue: 4
  • Publication Date: 2020
  • Doi Number: 10.1016/j.aller.2020.03.002
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, DIALNET
  • Page Numbers: pp.323-331
  • Keywords: Atopy patch test, Cow's milk allergy, Hen's egg allergy, Children, SKIN-PRICK TEST, FOOD ALLERGY, DIAGNOSTIC-ACCURACY, NATURAL-HISTORY, IGE
  • Dokuz Eylül University Affiliated: Yes


Introduction and objectives: Since early 2000s, atopy patch test (APT) has been used to deter-mine non-IgE and mixed-type food allergies. Previous studies have reported conflicting results about the diagnostic value of APT in food allergies, due to non-standardized methods. We aimed to determine the diagnostic efficacy of APT compared to open oral food chal-lenge (OFC) in patients diagnosed with cow's milk allergy (CMA) and hen's egg allergy (HEA) manifesting as atopic dermatitis (AD) and gastrointestinal system symptoms. Materials and methods: In patients with suspected AD and/or gastrointestinal manifestations due to CMA and HEA, the results of OFC, APT, skin prick test (SPT) and specific IgE (sIgE) were reviewed. Specificity, sensitivity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of sIgE, SPT, APT and SPT + APT were calculated. Results: In total 133 patients with suspected CMA (80) and HEA (53) were included in the study. In patients with CMA presenting with gastrointestinal symptoms, APT had sensitivity of 9.1%, specificity of 100%, PPV of 100% and NPV of 48.7%. In atopic dermatitis patients, sensitivity of APT was 71.4%, specificity 90.6%, PPV 62.5% and NPV 93.6%. In patients diagnosed with HEA, the sensitivity, specificity, PPV and NPV values of APT were 72.0%, 78.6%, 47.2% and 75.0%, respectively. In patients diagnosed with HEA presenting with AD, sensitivity of APT was 87.5%, specificity 70.6%, PPV 73.7% and NPV 85.7%. Atopy patch test had lower sensitivity (44.4%) and higher specificity (90.9%) in patients diagnosed with HEA presenting with gastrointestinal symptoms than those presenting with AD. Conclusion: Our study showed that APT provided reliable diagnostic accuracy in atopic dermatitis patients. However, APT had low sensitivity in patients with gastrointestinal symptoms. (C) 2019 SEICAP. Published by Elsevier Espana, S.L.U. All rights reserved.