Akademik Veri Yönetim Sistemi
16th European Congress of Endocrinology, Wroclaw, Polonya, 3 - 07 Mayıs 2014, ss.172-173
Low apelin levels are
associated with a marked increase in risk of gestational diabetes mellitus development
Background: Apelin is an adipokine which plays a role in the regulation of
glucose homeostasis. Relationships between serum apelin concentrations and dysmetabolic
conditions are still controversial. The aim of this study was to investigate
the association of serum apelin levels with gestational diabetes mellitus
(GDM).
Methods: This study was
designed as a cross-sectional research that consecutively recruited subjects
with GDM (n=38), without GDM pregnant (n=41), and non-pregnant healthy women
(n=39). Fasting blood glucose (FBG), serum apelin, insulin and lipids were
measured. BMI and HOMA-IR were calculated for all subjects. Logistic regression
analysis was performed to determine predictors of GDM development.
Results: Serum apelin levels (GDM = 1.99 ± 1.36 mg/ml, non-GDM pregnant =
2.95 ± 1.36 mg/ml, non-pregnant women = 2.62 ± 1.67 mg/ml) were significantly
lower (P = 0.017), HOMA-IR (P = 0.024) and BMI (P < 0.001) were
significantly higher in the GDM group compared with both the non-GDM and the
nonpregnant women. Serum apelin levels were found to be negatively correlated
with FBG (r = -0.236, P = 0.010), OGTT 1 h glucose (r = -0.346, P = 0.002)
& 2 h glucose (r = -0.248, P = 0.028), HbA1c (r = -0.209, P = 0.023),
HOMA-IR (r= -0.360, P < 0.001) and BMI (r = -0.299, P = 0.001).
Conclusions: Serum apelin levels were significantly lower in the GDM group as
compared with both the non-GDM pregnant and the non-pregnant healthy women. Low
apelin levels appear to be an independent predictor of GDM development.
Keywords
GDM, Apelin, HOMA-IR, HbA1c