Dopaminin kendiliğinden birleşen tek katmanlı altın elektrot üzerinde yeni bir moleküler baskılanmış polimer ile impedimetrik tespiti

Ertuğrul Uygun H. D., Demir M. N.

JOURNAL OF MATERIALS SCIENCE: MATERIALS IN ELECTRONICS, sa.36, ss.1-11, 2025 (SCI-Expanded)

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1007/s10854-025-14375-0
  • Dergi Adı: JOURNAL OF MATERIALS SCIENCE: MATERIALS IN ELECTRONICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aerospace Database, Applied Science & Technology Source, Chemical Abstracts Core, Communication Abstracts, Compendex, Computer & Applied Sciences, INSPEC, MEDLINE, Metadex, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.1-11
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Dopamine (DA), a neurotransmitter of the catecholamine class that has a range of functions in the mammalian central nervous system, is used to diagnose neurodegenerative diseases like schizophrenia, Parkinson’s illness, and Alzheimer’s disease. Therefore, it is an important biomarker to assess these diseases by measuring with low-cost, sensitive, and selective methods. In this research, we provided these advantages by engineering a molecularly imprinted impedimetric sensor to detect dopamine. The surface was modified with boronic acid residues and aminophenylboronic (APBA) acid and pyrrole-3-carboxylic (PyCOOH) acid were used as functional monomers around dopamine. Detection of dopamine was carried out by electrochemical impedance spectroscopy (EIS). According to the calibration curve between 100 and 600 pM (R2 = 0.9517), the sensor system’s performance parameters were established, and the limit of detection (LOD) and limit of quantification (LOQ) were discovered to be 30.34 and 95.82 pM, respectivey.