The relationship between sarcopenia detected in newly diagnosed colorectal cancer patients and FGF21, irisin and CRP levels

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Oflazoglu U., Caglar S., Yilmaz H. E., Onal H. T., Varol U., Salman T., ...More

EUROPEAN GERIATRIC MEDICINE, vol.13, no.4, pp.795-803, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 4
  • Publication Date: 2022
  • Doi Number: 10.1007/s41999-022-00635-3
  • Journal Name: EUROPEAN GERIATRIC MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
  • Page Numbers: pp.795-803
  • Keywords: Sarcopenia, Irisin, FGF21, Colorectal cancer, Bio-electric impedance analysis, BIOELECTRICAL-IMPEDANCE ANALYSIS, SKELETAL-MUSCLE MASS, CIRCULATING LEVELS, BODY-COMPOSITION, ADIPOSE-TISSUE, OBESITY, EXERCISE, SERUM, INFLAMMATION, EXPRESSION
  • Dokuz Eylül University Affiliated: Yes

Abstract

Key summary pointsAim We aimed to investigate the relationship between irisin and FGF21 in detecting sarcopenia in colorectal cancer patients. Findings Correlation analysis was performed between skeletal muscle mass index and FGF21, irisin and CRP, there was a positive correlation between skeletal muscle mass index and irisin and FGF21, while there was a negative correlation between skeletal muscle mass index and CRP. Message Irisin and FGF-21 and CRP may play a role in the pathophysiology of sarcopenia.