Cardiac Safety of Donepezil in Elderly Patients with Alzheimer Disease

IŞIK A. T., Yildiz G. B., Bozoglu E., Yay A., Aydemir E.

INTERNAL MEDICINE, vol.51, no.6, pp.575-578, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 6
  • Publication Date: 2012
  • Doi Number: 10.2169/internalmedicine.51.6671
  • Journal Name: INTERNAL MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.575-578
  • Keywords: Donepezil, cardiac safety, Alzheimer Disease, elderly, QT interval
  • Dokuz Eylül University Affiliated: Yes

Abstract

Objective Donepezil is a widely used cholinesterase inhibitor for the treatment of Alzheimer's disease (AD), however its cholinergic adverse side effects on the cardiovascular system are still unclear. In this study, we aimed to examine the adverse side effects caused by donepezil on cardiac rhythm and postural blood pressure changes in elderly patients with Alzheimer Disease.