The SystemCHANGE™ intervention improves immunosuppressive medication-taking habit: a secondary analysis of the MAGIC studies
Transplant international : official journal of the European Society for Organ Transplantation, cilt.39, ss.16252, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 39
- Basım Tarihi: 2026
- Doi Numarası: 10.3389/ti.2026.16252
- Dergi Adı: Transplant international : official journal of the European Society for Organ Transplantation
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals, Academic Search Ultimate (EBSCO), Health Research Premium Collection (ProQuest), Pharma Collection (ProQuest)
- Sayfa Sayıları: ss.16252
- Anahtar Kelimeler: adults, habit strength, kidney transplantation, medication adherence, secondary analysis
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Dokuz Eylül Üniversitesi Adresli: Evet
Özet
Habit impacts healthy behaviors. The SystemCHANGE™ intervention supports associating medication taking with existing habits or creating new habits to improve medication adherence. This secondary analysis of United States and Türkiye MAGIC study data examines differences in habit between SystemCHANGE™ and attention control groups, differences in habit between countries, and habit as a relationship mediator between the SystemCHANGE™ intervention and immunosuppressive medication adherence in adult kidney transplant recipients. The Medication Event Monitoring System measured medication adherence. Objective habit index was computed during screening, intervention, and maintenance. During the SystemCHANGE™ intervention, habit strength was higher than during the screening and maintenance periods in both groups (mean difference 0.042, 95% confidence interval (CI): 0.004 to 0.080, p = 0.030). Habit index was lower for US participants compared to Turkish participants (mean difference -0.195, 95% CI: -0.300 to -0.089, p < 0.001). Habit was a mediator of the SystemCHANGE™ intervention on medication adherence (indirect effect was 0.094, 95% CI: 0.080 to 0.114, p < 0.001). The SystemCHANGE™ intervention exerted an impact on habit in two different populations which then had a positive impact on medication adherence.