Expression and activity levels of matrix metalloproteinase-7 and in situ localization of caseinolytic activity in colorectal cancer

Keles D., Arslan B., Terzi C., Tekmen I., Dursun E., ALTUNGÖZ O., ...More

CLINICAL BIOCHEMISTRY, vol.47, pp.1265-1271, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 47
  • Publication Date: 2014
  • Doi Number: 10.1016/j.clinbiochem.2014.06.004
  • Journal Name: CLINICAL BIOCHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1265-1271
  • Keywords: Matrix metalloproteinase-7, Casein zymography, In situ casein zymography, Colorectal cancer, BETA-CATENIN, PROGNOSTIC-SIGNIFICANCE, COLON-CANCER, MATRILYSIN EXPRESSION, RECTAL-CANCER, GROWTH, CELLS, MMP-7, ACTIVATION, CARCINOMA
  • Dokuz Eylül University Affiliated: Yes

Abstract

Objectives: Matrix metalloproteinase-7 is capable of degrading several ECM and non-ECM molecules and contributes to colorectal cancer progression and metastasis. Here, we examined the significance of MMP-7 in colorectal tumors by detecting active and latent MMP-7 levels and localization of its caseinolytic activity.