The Relationship Between Carotid Intima Media Thickness, Inflammation and GLA Rich Protein Levels in Chronic Kidney Disease

Demirci R., SEVİNÇ C.

INTERNATIONAL JOURNAL OF GENERAL MEDICINE, vol.14, pp.5119-5126, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14
  • Publication Date: 2021
  • Doi Number: 10.2147/ijgm.s331758
  • Journal Name: INTERNATIONAL JOURNAL OF GENERAL MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, Directory of Open Access Journals
  • Page Numbers: pp.5119-5126
  • Keywords: chronic kidney disease, carotid intima media thickness, inflammation, GLA rich protein, VASCULAR CALCIFICATION, CARDIOVASCULAR-DISEASE, RISK-FACTORS, ASSOCIATION, RATIO, EXPRESSION, OUTCOMES
  • Dokuz Eylül University Affiliated: No

Abstract

Aim: Vascular calcification is a common complication in CKD. Studies conducted in patients with end-stage renal disease (ESRD) showed that calcification in vascular structures is an important component of the atherosclerosis process. GLA rich protein (GRP) has been suggested as a potential marker for vascular calcification. We investigated the relationship between GRP levels, carotid intima media thickness and inflammatory parameters in patients with predialysis stage 3, 4 and 5 CKD.