Investigation of magnetic properties of various complexes prepared as contrast agents for MRI

Yurt A., Kazancı N.

JOURNAL OF MOLECULAR STRUCTURE, vol.892, no.1-3, pp.392-397, 2008 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 892 Issue: 1-3
  • Publication Date: 2008
  • Doi Number: 10.1016/j.molstruc.2008.06.024
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.392-397
  • Keywords: Superparamagnetic particles, Relaxivity, Contrast agent, Magnetic resonance imaging, Experimental, BOVINE SERUM-ALBUMIN, PROTON RELAXATION, SUPERPARAMAGNETIC PARTICLES, RESONANCE, NANOPARTICLES, MANGANESE(II), RELAXIVITY, BINDING, MEDIA, WATER
  • Dokuz Eylül University Affiliated: Yes


In this study, the relaxivities of various ferri-ferro and superparamagnetic particles in human serum and deionized water were determined by using MRI system operating at 1.5 T. For this purpose, the spin-lattice (1/T-1) and spin-spin (1/T-2) relaxation rates in serum and deionized water were measured versus increasing concentrations of the DyPO4, 5Fe(2)O(3)3Gd(2)O(3) + dextran, 5Fe(2)O(3)3Gd(2)O(3) + CMC, 5Fe(2)O(3)3Gd(2)O(3). The longitudinal relaxivity (r(1)) and transverse relaxivity (r(2)) of proton were determined from the slopes of fits between the relaxation rates and concentrations.