The Effect of Differentiating and Apoptotic Agents on Notch Signalling Pathway in Hepatoblastoma

AKTAŞ S., Zadeoglulari Z., Ercetin P., Olgun N.

HEPATO-GASTROENTEROLOGY, vol.57, no.101, pp.891-898, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 57 Issue: 101
  • Publication Date: 2010
  • Journal Name: HEPATO-GASTROENTEROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.891-898
  • Keywords: Hepatoblastoma, Notch, Chemotherapy, BETA-CATENIN, HISTOLOGIC SUBTYPES, PEDIATRIC ONCOLOGY, ARSENIC TRIOXIDE, GROWTH, CISPLATIN, CHILDREN, NEUROBLASTOMA, DOXORUBICIN, ACTIVATION
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background/Aims: Notch expression is not yet determined in hepatoblastoma. In this study the effect of chemotherapeutics (cisplatin, doxorubicin, cytosin arabinoside); differentiating agent (13 cis-retinoic acid) and apoptotic agents (5-aza-2'-deoxycytidine, arsenic trioxide) on notch expression in hepatoblastoma were evaluated.