The Effect of Differentiating and Apoptotic Agents on Notch Signalling Pathway in Hepatoblastoma

AKTAŞ S., Zadeoglulari Z., Ercetin P., Olgun N.

HEPATO-GASTROENTEROLOGY, cilt.57, sa.101, ss.891-898, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 57 Sayı: 101
  • Basım Tarihi: 2010
  • Dergi Adı: HEPATO-GASTROENTEROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.891-898
  • Anahtar Kelimeler: Hepatoblastoma, Notch, Chemotherapy, BETA-CATENIN, HISTOLOGIC SUBTYPES, PEDIATRIC ONCOLOGY, ARSENIC TRIOXIDE, GROWTH, CISPLATIN, CHILDREN, NEUROBLASTOMA, DOXORUBICIN, ACTIVATION
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background/Aims: Notch expression is not yet determined in hepatoblastoma. In this study the effect of chemotherapeutics (cisplatin, doxorubicin, cytosin arabinoside); differentiating agent (13 cis-retinoic acid) and apoptotic agents (5-aza-2'-deoxycytidine, arsenic trioxide) on notch expression in hepatoblastoma were evaluated.