Outbreak Caused by NDM-1-and RmtB-Producing Escherichia coli in Bulgaria
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol.58, no.4, pp.2472-2474, 2014 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 58 Issue: 4
- Publication Date: 2014
- Doi Number: 10.1128/aac.02571-13
- Journal Name: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.2472-2474
- Dokuz Eylül University Affiliated: No
Abstract
Twelve consecutive carbapenem-resistant Escherichia coli isolates were recovered from patients (infection or colonization) hospitalized between March and September 2012 in different units at a hospital in Bulgaria. They all produced the carbapenemase NDM-1 and the extended-spectrum-beta-lactamase CTX-M-15, together with the 16S rRNA methylase RmtB, conferring high-level resistance to all aminoglycosides. All those isolates were clonally related and belonged to the same sequence type, ST101. In addition to being the first to identify NDM-producing isolates in Bulgaria, this is the very first study reporting an outbreak of NDM-1-producing E. coli in the world.