Leptin levels in boys with pubertal gynecomastia

Dundar B., Dundar N., Erci T., Bober E., Buyukgebiz A.

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, vol.18, no.10, pp.929-934, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 10
  • Publication Date: 2005
  • Doi Number: 10.1515/jpem.2005.18.10.929
  • Journal Name: JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.929-934
  • Keywords: leptin, puberty, gynecomastia, BODY-MASS INDEX, SEXUAL-MATURATION, ADIPOSE-TISSUE, GROWTH-FACTOR, CELL-LINE, AROMATASE, CHILDREN, RECEPTOR, GENDER, ADOLESCENTS
  • Dokuz Eylül University Affiliated: No

Abstract

Background: It has been reported that there is a relationship between circulating leptin and sex steroid hormones and leptin is able to stimulate estrogen secretion by increasing aromatase activity in adipose stromal cells and breast tissue. Leptin receptors have been also shown in mammary epithelial cells and it has been suggested that leptin is involved in the control of the proliferation of both normal and malignant breast cells.