Evaluation of c-kit (CD 117) expression as a prognostic factor in testicular germ cell tumors: an Izmir Oncology Group (IZOG) study

Salman T., Yildiz E., Yildiz I., Yayuzer D., Unlu M., Varol U., ...More

JOURNAL OF BUON, vol.20, no.4, pp.1054-1060, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 4
  • Publication Date: 2015
  • Journal Name: JOURNAL OF BUON
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1054-1060
  • Keywords: carcinogenesis, CD 117, c-Kit, ernbryogenesis, germ cell tumors, testicular cancer, GROWTH-FACTOR RECEPTOR, IMATINIB MESYLATE, PHASE-II, COMPLETE RESPONSE, TYROSINE KINASE, CANCER, CHEMOTHERAPY, SEMINOMA, CLASSIFICATION, BEVACIZUMAB
  • Dokuz Eylül University Affiliated: Yes

Abstract

Purpose: Despite the successful use of targeted and molecular therapies in other cancers, little progress has been made in the management of testicular germ cell tumors (TGCTs). c-kit (CD 117) is a good target for cancer treatment and possesses an impressive role in the current oncological practice. We aimed to evaluate c-kit expression in early stage TGCTs as a prognostic factor.