Changes of serum macro and trace element in hyperketonemic goats

Okulmus Ç., Turan D., Turkyilmaz O., Kiziltep S.

ARQUIVO BRASILEIRO DE MEDICINA VETERINARIA E ZOOTECNIA, cilt.77, sa.4, 2025 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 77 Sayı: 4
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1590/1678-4162-134
  • Dergi Adı: ARQUIVO BRASILEIRO DE MEDICINA VETERINARIA E ZOOTECNIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, Directory of Open Access Journals
  • Anahtar Kelimeler: Chondrogenesis, programmed cell death, triiodothyronine, stem cells, rats
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

In this trial, changes in macro and trace element concentrations and the relationships between these changes and glucose (Glu), (3-hydroxybutyrate ((3HB) and non-esterified fatty acid (NEFA) parameters were evaluated in hyperketonemic goats. Goat blood serum submitted to the laboratory for routine metabolic profile test were used as the study material. Serum with (3HB concentrations >0.8mmol/L constituted the hyperketonemia group and those with concentrations <0.8mmol/L constituted the control group. Trace element concentrations of serum samples were measured using inductively coupled plasma mass spectrometry (ICP-MS). Hyperketonemia group goats had significantly higher levels of (3HB, NEFA and aspartate transaminase (AST) and lower levels of Glu, triglyceride (TG) and alkaline phosphatase (ALP) compared to control group goats (p (Cr) levels were lower, and cobalt (Co) levels were higher in the hyperketonemic group (p<0.05). In addition, some elements had significant correlations with (3HB, NEFA and Glu, the main metabolic markers of ketosis (p<0.05). The results of this study showed that hyperketonemia induced significant changes in blood element hemostasis in goats and this process may be closely related to energy metabolism.