HEPATIC-PORTAL AND CARDIAC INFUSION OF CCK-8 AND GLUCAGON INDUCE DIFFERENT EFFECTS ON FEEDING

STRUBBE J., WOLSINK J., SCHUTTE A., KUVAKİ BALKAN B., PRINS A.

PHYSIOLOGY & BEHAVIOR, vol.46, no.4, pp.643-646, 1989 (SCI-Expanded, Scopus) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 4
  • Publication Date: 1989
  • Doi Number: 10.1016/0031-9384(89)90345-4
  • Journal Name: PHYSIOLOGY & BEHAVIOR
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.643-646
  • Dokuz Eylül University Affiliated: No

Abstract

In order to compare effects of circulating CCK-8 and glucagon on food intake, rats were provided with a permanently implanted catheter in the right atrium. Another cannula was implanted into the hepatic-portal vein by a new technique. After a standard fasting period graded loads of CCK-8 and glucagon were infused via these catheters during refeeding. Intracardiac glucagon and CCK loads dose-dependency suppressed meal size. Intraportal infusion of glucagon caused similar suppression compared to intracardiac administration. This may indicate a minor role of the liver as a target for the suppression of feeding by glucagon. In contrast, intraportal infusion of CCK-8 did not reduce food intake. The results indicate that CCK-8 is removed or inactivated by the liver. It is suggested that CCK-8 acts locally on vagal nerve endings to exert its suppressive action on food intake.