Fetal HLA-G alleles and their effect on miscarriage

Koc A., Kirbiyik O., Kutbay Y. B., Ozyilmaz B., Ozdemir T. R., Kaya O. O., ...More

ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, vol.27, no.9, pp.1233-1237, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 9
  • Publication Date: 2018
  • Doi Number: 10.17219/acem/69692
  • Journal Name: ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1233-1237
  • Keywords: miscarriage, human leukocyte antigen-G, G*01:04, 3' untranslated region polymorphism, PREGNANCY, CELLS, INTERFACE
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background. Immunosuppression at the feto-maternal interface is crucial for a successful pregnancy outcome. Human leukocyte antigen-G (HLA-G) seems to be a major contributor to fetal tolerance. The HLA-G expression is seen in cytotrophoblasts and in maternal blood. Fetal HLA-G acts on decidual antigen-presenting cells (APCs), natural killers (NKs) and T cells. Recent findings revealed that defects in placentation and their consequences are associated with maternal HLA-G variants and their expression levels.