Fetal HLA-G alleles and their effect on miscarriage

Koc A., Kirbiyik O., Kutbay Y. B., Ozyilmaz B., Ozdemir T. R., Kaya O. O., ...Daha Fazla

ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, cilt.27, sa.9, ss.1233-1237, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 9
  • Basım Tarihi: 2018
  • Doi Numarası: 10.17219/acem/69692
  • Dergi Adı: ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1233-1237
  • Anahtar Kelimeler: miscarriage, human leukocyte antigen-G, G*01:04, 3' untranslated region polymorphism, PREGNANCY, CELLS, INTERFACE
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background. Immunosuppression at the feto-maternal interface is crucial for a successful pregnancy outcome. Human leukocyte antigen-G (HLA-G) seems to be a major contributor to fetal tolerance. The HLA-G expression is seen in cytotrophoblasts and in maternal blood. Fetal HLA-G acts on decidual antigen-presenting cells (APCs), natural killers (NKs) and T cells. Recent findings revealed that defects in placentation and their consequences are associated with maternal HLA-G variants and their expression levels.