The effects of gender and menopause on serum lidocaine levels in smokers
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, vol.30, no.4, pp.231-234, 2005 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 30 Issue: 4
- Publication Date: 2005
- Doi Number: 10.1007/bf03190625
- Journal Name: EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.231-234
- Keywords: lidocaine, CYP1A2, CYP3A4, gender, menopause
- Dokuz Eylül University Affiliated: Yes
Abstract
it has been established that human cytochrome P450 (CYP) enzymatic activity is affected by gender, or by hormonal factors such as the menopause in women. Gender differences have a more pronounced effect on cytochrome (CYP) 3A4 isoenzyme activity, whereas cytochrome (CYP) 1A2 isoenzyme activity is mainly induced by chronic smoking. Lidocaine is frequently used in the treatment of hemodynamic changes following laryngoscopy and tracheal intubation during general anesthesia, and is metabolized by CYP3A4 and CYP1A2 isoenzymes in the liver.