© 2015 Gazi Eye Foundation. All rights reserved.Purpose: To evaluate the vitreoretinal interface with spectral domain optical coherence tomography (SD-OCT) in patients with asteroid hyalosis. Materials and Methods: Fourty-nine eyes of 40 patients who were diagnosed with asteroid hyalosis in our clinic between January 2012 and May 2014 were included in the study. Cases with previously diagnosed pathologies that may cause any vitreoretinal interface abnormalities such as uveitis, retinal vein occlusion and diabetic retinopathy as well as those who had a history of ocular laser, surgery and trauma were excluded from the study. A detailed ophthalmologic examination including SD-OCT scan was performed in all study participants and any vitreoretinal interface abnormalities were noted. Results: Mean age of the study group was 69.5±8.8 years (Range, 49-86 years) at the time of diagnosis, twenty eight were men (70%) and twelve female (30%). Bilateral involvement was present in 9 patients (22.5%). Of the total 49 eyes, vitreoretinal interface was normal in 23 eyes (46.9%); while interface abnormality was found in 26 eyes (53.1%). Among 49 eyes, 15 (30.6%) had epiretinal membrane, 9 (18.4%) vitreomacular adhesion, and 2 (4.1%) vitreomacular traction. Conclusion: There may be vitreoretinal interface abnormalities in patients with asteroid hyalosis. Asteroid bodies may limit the clear view of the macula and vitreomacular interface. As vitreoretinal interface abnormalities may be the main cause of visual deterioration in eyes with asteroid hyalosis, optic coherence tomography should be performed in such cases.