Effect of sildenafil citrate on postprandial gallbladder motility

Degirmenci B., Acar M., Albayrak R., Yucel A., Haktanir A., Demirel R., ...More

SOUTHERN MEDICAL JOURNAL, vol.99, no.3, pp.208-211, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 99 Issue: 3
  • Publication Date: 2006
  • Doi Number: 10.1097/01.smj.0000203333.29270.54
  • Journal Name: SOUTHERN MEDICAL JOURNAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.208-211
  • Keywords: gallbladder diseases, sildenafil citrate, ultrasonography, nitric oxide, LOWER ESOPHAGEAL SPHINCTER, NITRIC-OXIDE, HEALTHY-SUBJECTS, ORAL SILDENAFIL, MOTOR FUNCTION, PATHWAY
  • Dokuz Eylül University Affiliated: No

Abstract

Objective: Sildenafil stimulates the nitric oxide-cyclic guanosine monophosphate (NO-cGMP) pathway through inhibition of type 5 phosphodiesterase. NO-cGMP pathway causes smooth muscle relaxation. The aim of this study is to evaluate the effects of sildenafil on gallbladder motility.