Divergent effects of first-generation and second-generation antipsychotics on cortical thickness in first-episode psychosis

Ansell B. R. E., Dwyer D. B., Wood S. J., BORA İ. E., Brewer W. J., Proffitt T. M., ...Daha Fazla

PSYCHOLOGICAL MEDICINE, cilt.45, sa.3, ss.515-527, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 3
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1017/s0033291714001652
  • Dergi Adı: PSYCHOLOGICAL MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Sayfa Sayıları: ss.515-527
  • Anahtar Kelimeler: Antipsychotics, cortical thickness, first-episode psychosis, first-generation, second-generation, GRAY-MATTER VOLUME, HUMAN CEREBRAL-CORTEX, ATYPICAL ANTIPSYCHOTICS, CHRONIC-SCHIZOPHRENIA, BIPOLAR DISORDER, GREY-MATTER, BLOOD-FLOW, BRAIN, ABNORMALITIES, DRUGS
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background. Whether there are differential effects of first-generation antipsychotics (FGAs) and second-generation antipsychotics (SGAs) on the brain is currently debated. Although some studies report that FGAs reduce grey matter more than SGAs, others do not, and research to date is limited by a focus on schizophrenia spectrum disorders. To address this limitation, this study investigated the effects of medication in patients being treated for first-episode schizophrenia or affective psychoses.