New morpholine-liganded palladium(II) N-heterocyclic carbene complexes: Synthesis, characterization, crystal structure, and DNA-binding studies


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Turker F., Gürses C., Barut Celepci D., Aktaş A., Ateş B., Gök Y.

ARCHIV DER PHARMAZIE, vol.352, no.12, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 352 Issue: 12
  • Publication Date: 2019
  • Doi Number: 10.1002/ardp.201900187
  • Journal Name: ARCHIV DER PHARMAZIE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: DNA binding, N-heterocyclic carbene, structure elucidation, substituent effect, synthesis, CATALYTIC-ACTIVITY, SILVER(I)-N-HETEROCYCLIC CARBENE, RUTHENIUM(II) COMPLEXES, CARBONIC-ANHYDRASE, RECENT PROGRESS, ANTICANCER, CYTOTOXICITY, AGENTS, SALTS
  • Dokuz Eylül University Affiliated: Yes

Abstract

A series of the morpholine-liganded palladium(II) complexes (1a-e) bearing N-heterocyclic carbene (NHC) functionalized by benzonitrile were synthesized. These complexes were synthesized from (NHC)Pd(II)(pyridine) complexes (PEPPSI) and morpholine. The new complexes were fully characterized by using H-1 NMR, C-13 NMR, Fourier-transform infrared spectroscopy, and elemental analysis techniques. Single-crystal X-ray diffraction was used to determine the structure of a derivative. The DNA-binding studies of the new (NHC)Pd(II)morpholine complexes were examined using the pBR322 plasmid. The 2,4,6-trimethylbenzyl derivative compound has the most DNA binding activity. In addition, for the 3-methylbenzyl derivative compound, oxidation effects were observed at concentrations higher than 100 mu g/ml. Also, the molecular and crystal structures of the complex 3-methylbenzyl derivative compound were recorded by using a single-crystal X-ray diffraction method.