Akademik Veri Yönetim Sistemi
26. Ulusal ve 1. Uluslararası Farmakoloji Kongresi , İzmir, Türkiye, 4 - 06 Kasım 2021, ss.384
Objectives: To determine the prevalence of and the risk factors for Potentialy Inappropriate Medication (PIM), the drug groups most
commonly evaluated as PIMs in elderly patients in the ICUs by using 2019 Beers Criteria, STOPP version2(v2) Criteria and EU(7)-PIM List. The
relation between mortality rate and length of ICU stay with PIMs was also examined.
Materials-Methods: This was a cross sectional study conducted on patients aged ≥65 years, treated in ICUs(n=139) between June 8, 2020
and January 11, 2021. Patients’ demographic characteristics, clinical data and laboratory findings about the used drugs were collected
prospectively. PIMs were evaluated according to each of the criteria applied. Relationship of dependent and independent variables was
evaluated using chi-square analysis, t-test and logistic regression analysis. P<0.05 was considered statistically significant.
Results: The number of patients with at least 1 PIM according to three criteria was 118(84.9%) (80.6%, 59.7%, 48.2%, Beers, STOPP/v2 and
EU(7)-PIM List, respectively). In the univariate analysis, receiving renal replacement therapy and high number of drugs were the covariates
that significantly affected the presence of PIM according to all three criteria (p<0.05). Combined use of anxiolytics and opioids in Beers
Criteria (58.3%), antipsychotics (26.6%) in STOPP/v2 Criteria, and antiarrhythmics (23.7%) in EU(7)-PIM List were the drugs that caused PIM
at most. No relationship was found between the presence of PIM and mortality. Length of ICU stay was determined significantly longer in
the presence of PIM according to Beers Criteria (p=0.028).
Conclusions: In this study, the prevalence of PIM was determined higher in elderly patients in ICU. Our results supported that 2019 Beers
Criteria for ICU patients seems to be more directive in detecting PIMs and determining the prognosis. Reducing the number of drugs
administered may be the first step to decrease PIMs in elderly patients in ICU and to maintain the treatment safely.
Keywords: Potentially inappropriate medication, intensive care unit, Beers Criteria, STOPP Criteria, EU(7)-PIM List