Akademik Veri Yönetim Sistemi
JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES, cilt.8, ss.181-191, 2024 (ESCI)
Aim: Our study aimed to establish a mouse model with colorectal cancer-induced peritoneal
metastasis(PM) and to compare the efficacy of hyperthermic intraperitoneal chemotherapeutic agents,
mitomycin C and oxaliplatin.
Materials and Methods: The peritoneal metastasis model was established in nude mice using the CC531
colon carcinoma cell line. Models with PM were randomized into four groups of seven animals each:
Group-1, control group; Group-2, hyperthermic intraperitoneal chemotherapy(HIPEC) with mitomycin
C(MMC), and Group-3, HIPEC with Oxaliplatin(OXA).
Results: Tumor development was achieved in all animals. While the tumor burden decreased significantly
in the treatment Group-2(p=.013). In the PM mouse model, hyperthermic intraperitoneal administration of
MMC had a higher tumoricidal effect than hyperthermic intraperitoneal administration of OXA.
Conclusions: Our PM model provided a good opportunity to examine the efficacy of HIPEC and IPIP.
Hyperethermic intraperitoneal mitomycin applied in the colorectal PM animal model was found to have
higher tumoricidal activity than oxaliplatin. In future studies, we plan to evaluate efficacies of different
drugs in the PM models we have created.