Akademik Veri Yönetim Sistemi
Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2026, California, Amerika Birleşik Devletleri, 19 - 21 Ocak 2026, cilt.13829, (Tam Metin Bildiri)
Familial Mediterranean Fever (FMF) is an inherited autoinflammatory disease caused by mutations in the Mediterranean Fever (MEFV) gene that lead to abnormal expression of the pyrin protein and uncontrolled inflammatory responses. Without a timely diagnosis, patients face a high risk of irreversible complications, most notably amyloidosis and permanent organ damage. This makes early intervention not just a clinical goal, but a necessity for patient survival. However, current diagnostic methods have several limitations. They rely heavily on genetic testing, which is often slow, expensive, and sometimes inconclusive. To bridge this gap, we developed a label-free plasmonic biosensor designed to detect pyrin directly from blood samples. By utilizing gold nanoparticle-based chips functionalized with specific anti-pyrin antibodies, we achieved a remarkable detection limit of 0.24ng/mL. In a clinical validation with 30 patient samples, our platform successfully distinguished between FMF-positive cases and healthy controls, showing excellent agreement with standard ELISA results. Crucially, the entire analysis is completed in under 30 minutes with minimal sample preparation. This approach offers a much-needed rapid and cost-effective alternative for FMF screening in clinical settings.