Assessment of Protective Effects of Methylprednisolone and Pheniramine Maleate on Reperfusion Injury in Kidney After Distant Organ Ischemia: A Rat Model

Bayrak S., Yurekli I., Gokalp O., KİRAY M., Bademci M. S., Ozcem B., ...More

ANNALS OF VASCULAR SURGERY, vol.26, no.4, pp.559-565, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 4
  • Publication Date: 2012
  • Doi Number: 10.1016/j.avsg.2012.01.006
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.559-565
  • Dokuz Eylül University Affiliated: Yes


Background: Ischemia/reperfusion (I/R) injury of tissues is a common problem that cardiovascular surgeons are faced with. Suppression of inflammation, which plays an important role in the pathogenesis of I/R injury, may reduce this damage. The aim of this study is to investigate the protective effects of methylprednisolone (MP)-a potent anti-inflammatory agent-and pheniramine maleate (FM)-an antihistamine that also has some anti-inflammatory effects-on reperfusion injury of kidneys developing after ischemia of the left lower extremity of rats.