ANNALS OF VASCULAR SURGERY, cilt.26, sa.4, ss.559-565, 2012 (SCI-Expanded)
Background: Ischemia/reperfusion (I/R) injury of tissues is a common problem that cardiovascular surgeons are faced with. Suppression of inflammation, which plays an important role in the pathogenesis of I/R injury, may reduce this damage. The aim of this study is to investigate the protective effects of methylprednisolone (MP)-a potent anti-inflammatory agent-and pheniramine maleate (FM)-an antihistamine that also has some anti-inflammatory effects-on reperfusion injury of kidneys developing after ischemia of the left lower extremity of rats.