The Analgesic Effect of Dexketoprofen When Added to Lidocaine for Intravenous Regional Anaesthesia: a Prospective, Randomized, Placebo-controlled Study

YURTLU B. S., HANCI V., Kargi E., Erdogan G., Koksal B. G., Gul S., ...Daha Fazla

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, cilt.39, sa.5, ss.1923-1931, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39 Sayı: 5
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1177/147323001103900537
  • Dergi Adı: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1923-1931
  • Anahtar Kelimeler: INTRAVENOUS REGIONAL ANAESTHESIA, DEXKETOPROFEN, LIDOCAINE, ANTIINFLAMMATORY DRUG, KETOROLAC, SURGERY, HAND, ANTINOCICEPTION, CYCLOOXYGENASE, NIMESULIDE, PRILOCAINE, LORNOXICAM, INHIBITORS
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

This prospective, randomized, placebo-controlled study evaluated the effects of dexketoprofen as an adjunct to lidocaine in intravenous regional anaesthesia (IVRA) or as a supplemental intravenous (i.v.) analgesic. Patients scheduled for elective hand or forearm soft-tissue surgery were randomly divided into three groups. All 45 patients received 0.5% lidocaine as IVRA. Dexketoprofen was given either i.v. or added into the IVRA solution and the control group received an equal volume of saline both i.v. and as part of the IVRA. The times of sensory and motor block onset, recovery time and postoperative analgesic consumption were recorded. Compared with controls, the addition of dexketoprofen to the IVRA solution resulted in more rapid onset of sensory and motor block, longer recovery time, decreased intra- and postoperative pain scores and decreased paracetamol use. It is concluded that coadministration of dexketoprofen with lidocaine in IVRA improves anaesthetic block and decreases postoperative analgesic requirements.