Thiazide therapy is not related to any changes in cognitive function in older hypertensive patients with or without dementia: a 26-week follow-up study


Kocyigit S. E., Soysal P., Ates Bulut E., Dokuzlar O., IŞIK A. T.

PSYCHOGERIATRICS, vol.19, no.1, pp.16-22, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 1
  • Publication Date: 2019
  • Doi Number: 10.1111/psyg.12353
  • Journal Name: PSYCHOGERIATRICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.16-22
  • Keywords: cognitive function, diuretic, elderly, hypertension, thiazide, LIPID-LOWERING TREATMENT, ALZHEIMERS-DISEASE, BLOOD-PRESSURE, ANTIHYPERTENSIVE DRUGS, INCIDENT DEMENTIA, GINKGO EVALUATION, DOUBLE-BLIND, RISK, PREVENTION, TRIAL
  • Dokuz Eylül University Affiliated: Yes

Abstract

Aim The study aimed to evaluate the effect of thiazide diuretics, a first-line antihypertensive therapy, on cognitive function in elderly hypertensive patients with or without cognitive impairment. Methods This retrospective and observational study assessed 286 elderly patients with hypertension. Patients were divided based on thiazide diuretic usage and then into dementia and non-dementia groups. The comprehensive geriatric assessment was performed for all patients. All participants were re-evaluated after a 26-week period. Results In total, 133 patients, including 62 with dementia, took thiazide. There were no significant differences between baseline and follow-up laboratory findings, comprehensive geriatric assessment parameters, including detailed neurocognitive assessment, or electrolytes in the thiazide group, the non-thiazide group, and the dementia group (P > 0.05). Conclusion Thiazide therapy does not show any effect on cognitive function in older hypertensive adults regardless of dementia status.