Regulation of Noncoding Transcriptome in Developing Photoreceptors by Rod Differentiation Factor NRL

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Zelinger L., KARAKÜLAH G., Chaitankar V., Kim J., Yang H., Brooks M. J., ...Daha Fazla

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, cilt.58, sa.11, ss.4422-4435, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 58 Sayı: 11
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1167/iovs.17-21805
  • Dergi Adı: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.4422-4435
  • Anahtar Kelimeler: lncRNA, gene regulation, RNA profiling, photoreceptor development, DORSAL-ROOT GANGLION, GENE-EXPRESSION, HUMAN GENOME, SEQ REVEALS, CHIP-SEQ, BC1 RNA, EVOLUTION, NETWORK, NEURONS, CELLS
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

PURPOSE. Transcriptome analysis by next generation sequencing allows qualitative and quantitative profiling of expression patterns associated with development and disease. However, most transcribed sequences do not encode proteins, and little is known about the functional relevance of noncoding (nc) transcriptome in neuronal subtypes. The goal of this study was to perform a comprehensive analysis of long noncoding (lncRNAs) and antisense (asRNAs) RNAs expressed in mouse retinal photoreceptors.