Regulation of Noncoding Transcriptome in Developing Photoreceptors by Rod Differentiation Factor NRL

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Zelinger L., KARAKÜLAH G., Chaitankar V., Kim J., Yang H., Brooks M. J., ...More

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol.58, no.11, pp.4422-4435, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 58 Issue: 11
  • Publication Date: 2017
  • Doi Number: 10.1167/iovs.17-21805
  • Journal Name: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.4422-4435
  • Keywords: lncRNA, gene regulation, RNA profiling, photoreceptor development, DORSAL-ROOT GANGLION, GENE-EXPRESSION, HUMAN GENOME, SEQ REVEALS, CHIP-SEQ, BC1 RNA, EVOLUTION, NETWORK, NEURONS, CELLS
  • Dokuz Eylül University Affiliated: Yes

Abstract

PURPOSE. Transcriptome analysis by next generation sequencing allows qualitative and quantitative profiling of expression patterns associated with development and disease. However, most transcribed sequences do not encode proteins, and little is known about the functional relevance of noncoding (nc) transcriptome in neuronal subtypes. The goal of this study was to perform a comprehensive analysis of long noncoding (lncRNAs) and antisense (asRNAs) RNAs expressed in mouse retinal photoreceptors.