A Puzzling Case of Phospho-Soda-induced Hypocalcemia in a Patient with Multiple Endocrine Neoplasia Type 1-associated Primary Hyperparathyroidism

Ozveren A., AKINCI B., MAKAY Ö., SARSIK KUMBARACI B., YILDIRIM ŞİMŞİR I., BERDELİ A., ...Daha Fazla

INTERNAL MEDICINE, cilt.51, sa.22, ss.3145-3149, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 22
  • Basım Tarihi: 2012
  • Doi Numarası: 10.2169/internalmedicine.51.7475
  • Dergi Adı: INTERNAL MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3145-3149
  • Anahtar Kelimeler: hypocalcemia, phospho-soda, MEN1, primary hyperparathyroidism, SODIUM-PHOSPHATE, SYMPTOMATIC HYPOCALCEMIA, HYPERPHOSPHATEMIA, COLONOSCOPY, TETANY, ADULT
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Although rare, symptomatic hypocalcemia may develop after the administration of phospho-soda. We herein present the case of a patient with phospho-soda-induced hypocalcemia who was surprisingly diagnosed with multiple endocrine neoplasia type 1 (MEN1) caused by a heterozygous mutation in the MEN1 gene (c628_631delACAG), thus resulting in a frameshift mutation (210ThrfsX224). In addition to being the first report of phospho-soda-induced hypocalcemia in a patient with MEN1-associated primary hyperparathyroidism, our report highlights the complex nature of calcium balance in the human body and helps clinicians to appreciate how confounding factors might affect the presentation of endocrine disorders.