Optimization of Different Surface Modifications for Binding of Tumor Cells in a Microfluidic Systems

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Meco H. E., Karadag A., Omeroglu S., Aydemir G., Çalıbaşı Koçal G., Oruc M. E., ...More

JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES, vol.3, no.2, pp.73-77, 2019 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 3 Issue: 2
  • Publication Date: 2019
  • Doi Number: 10.30621/jbachs.2019.601
  • Journal Name: JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.73-77
  • Keywords: Microfluidic Chips, Surface Modification, Cell Culture, CHIP
  • Dokuz Eylül University Affiliated: Yes

Abstract

Objectives:Microfluidic technology is a fast-growing area and provide high-efficient MEMS (Micro-Electro-Mechanical-Systems) sensor integration platform that helps to advance healthcare systems. Due to proper the chemical and mechanical properties of polymers, PDMS (Polydimethylsiloxane) (6) and PMMA (Poly-methyl-methacrylate), they became on the best candidate for health care studies in microfluidic studies (7). Besides, they perform great optical properties for observation of living cell experiments. To increase their performance, surface interactions works with cells, modification techniques are widely used in microfluidic chips. In this paper, our primary purpose is to modify such polymers and glass with matrigel, PDA and APTES so as to increase cell-surface interaction.