Beneficial effects of ursodeoxycholic acid via inhibition of airway remodelling, apoptosis of airway epithelial cells, and Th2 immune response in murine model of chronic asthma.

Isik, S.; Karaman, M.; Micili, SERAP; Caglayan-Sozmen, S.; BAĞRIYANIK, HÜSNÜ; Arikan-Ayyildiz, Z.; Uzuner, N.; Karaman, O.

doi:10.1016/j.aller.2016.12.003

Beneficial effects of ursodeoxycholic acid via inhibition of airway remodelling, apoptosis of airway epithelial cells, and Th2 immune response in murine model of chronic asthma.

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Isik S., Karaman M., Micili S., Caglayan-Sozmen S., BAĞRIYANIK H. A., Arikan-Ayyildiz Z., ...More

Allergologia et immunopathologia, vol.45, no.4, pp.339-349, 2017 (SCI-Expanded)

Publication Type: Article / Article
Volume: 45 Issue: 4
Publication Date: 2017
Doi Number: 10.1016/j.aller.2016.12.003
Journal Name: Allergologia et immunopathologia
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.339-349
Keywords: Asthma, Airway remodelling, Apoptosis, Ursodeoxycholic acid, Murine model, Th2, PRIMARY BILIARY-CIRRHOSIS, CHENODEOXYCHOLIC ACID, INFLAMMATION, EXPRESSION, EFFICACY, TRIAL, MECHANISMS, GALLSTONES, DISEASES, INJURY
Dokuz Eylül University Affiliated: Yes

Abstract

Background and aims: In previous studies, anti-inflammatory, anti-apoptotic and immunomodulatory effects of ursodeoxycholic acid (UDCA) on liver diseases have been shown. In this study, we aimed to investigate the effects of UDCA on airway remodelling, epithelial apoptosis, and T Helper (Th)-2 derived cytokine levels in a murine model of chronic asthma.