Design and in vitro, in vivo evaluation of antioxidant bioadhesive gelsfor burn treatment

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GÖKÇE G., KARAVANA S. Y., BAĞRIYANIK H. A., PEKÇETİN Ç., ALĞIN YAPAR E., AYBAR TURAL G., ...Daha Fazla

TURKISH JOURNAL OF BIOLOGY, cilt.46, sa.3, ss.251-262, 2022 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 3
  • Basım Tarihi: 2022
  • Doi Numarası: 10.55730/1300-0152.2612
  • Dergi Adı: TURKISH JOURNAL OF BIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.251-262
  • Anahtar Kelimeler: Taurine, antioxidant, bio-adhesive gel, burn wound model, MUCOADHESIVE, TAURINE, MELATONIN, CHITOSAN
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Burn wounds are frequently encountered health problems, which need a new treatment approach especially in terms of good patient compliance. Availability of use of antioxidant agents and bio-adhesive gels in tissue healing can be an alternative as a new approach for wound healing. Antioxidant taurine containing bio-adhesive gels were prepared by using carbopol (CP) 940 and 934. Rheological and texture analyses were carried out on bio-adhesive gels for in vitro characterization. Wound model on Wistar rats was used to evaluate the in vivo evaluation of gels. Rheological and texture analyses showed that a carbopol bioadhesive gel has acceptable topically use dosage characteristics and in combination with Taurine it presented a successful wound healing effect via antioxidant parameters. In conclusion, bio-adhesive CP 940 (2%) gel containing 50 mM taurine could be promising in the treatment of burns by oxidative stress.