Cooperative interaction of MUC1 with the HGF/c-Met pathway during hepatocarcinogenesis

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Bozkaya G., Korhan P., Cokakli M., Erdal E., SAĞOL Ö., Karademir S., ...Daha Fazla

MOLECULAR CANCER, cilt.11, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1186/1476-4598-11-64
  • Dergi Adı: MOLECULAR CANCER
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Hepatocellular carcinoma (HCC), Hepatocyte Growth Factor (HGF)/c-Met, Mucin 1 (MUC1), Differentiation, Invasion, HEPATOCYTE GROWTH-FACTOR, HEPATOCELLULAR-CARCINOMA, MOLECULAR PATHOGENESIS, FACTOR RECEPTOR, SCATTER FACTOR, BETA-CATENIN, EXPRESSION, CELL, P53, IDENTIFICATION
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background: Hepatocyte growth factor (HGF) induced c-Met activation is known as the main stimulus for hepatocyte proliferation and is essential for liver development and regeneration. Activation of HGF/c-Met signaling has been correlated with aggressive phenotype and poor prognosis in hepatocellular carcinoma (HCC). MUC1 is a transmembrane mucin, whose over-expression is reported in most cancers. Many of the oncogenic effects of MUC1 are believed to occur through the interaction of MUC1 with signaling molecules. To clarify the role of MUC1 in HGF/c-Met signaling, we determined whether MUC1 and c-Met interact cooperatively and what their role(s) is in hepatocarcinogenesis.