Cooperative interaction of MUC1 with the HGF/c-Met pathway during hepatocarcinogenesis


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Bozkaya G., Korhan P., Cokakli M., Erdal E., SAĞOL Ö., Karademir S., ...More

MOLECULAR CANCER, vol.11, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11
  • Publication Date: 2012
  • Doi Number: 10.1186/1476-4598-11-64
  • Journal Name: MOLECULAR CANCER
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Hepatocellular carcinoma (HCC), Hepatocyte Growth Factor (HGF)/c-Met, Mucin 1 (MUC1), Differentiation, Invasion, HEPATOCYTE GROWTH-FACTOR, HEPATOCELLULAR-CARCINOMA, MOLECULAR PATHOGENESIS, FACTOR RECEPTOR, SCATTER FACTOR, BETA-CATENIN, EXPRESSION, CELL, P53, IDENTIFICATION
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background: Hepatocyte growth factor (HGF) induced c-Met activation is known as the main stimulus for hepatocyte proliferation and is essential for liver development and regeneration. Activation of HGF/c-Met signaling has been correlated with aggressive phenotype and poor prognosis in hepatocellular carcinoma (HCC). MUC1 is a transmembrane mucin, whose over-expression is reported in most cancers. Many of the oncogenic effects of MUC1 are believed to occur through the interaction of MUC1 with signaling molecules. To clarify the role of MUC1 in HGF/c-Met signaling, we determined whether MUC1 and c-Met interact cooperatively and what their role(s) is in hepatocarcinogenesis.