Effects of repeated maternal separation on oxidative stress in adolescent male and female rat brains

UYSAL HARZADIN N., Sisman A., GÖNENÇ ARDA S., AÇIKGÖZ O., KAYATEKİN B. M., Yalaz G.

JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH, cilt.25, sa.3, ss.150-157, 2008 (SCI-Expanded, TRDizin) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 3
  • Basım Tarihi: 2008
  • Dergi Adı: JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.150-157
  • Anahtar Kelimeler: maternal separation, oxidative stress, lipid peroxidation, prefrontal cortex, hippocampus, striatum
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

In a previous study we demonstrated that repeated maternal separation impaired spatial memory performance in both male and female adolescent rats. The mechanisms of these cognitive alterations are unknown. In the present study, we examined the effects of repeated maternal separation on oxidative stress in the hippocampus, prefrontal cortex and striatum regions of the brain of the adolescent male and female rats. The results showed that repeated maternal separation increased antioxidant enzyme activities and lipid peroxidation in adolescent male rat brains; however, maternal separation did not effects antioxidant enzyme activities and lipid peroxidation in adolescent female rat brains. These results suggest that oxidative stress caused damage in repeated maternal separated adolescent male rat brains, also a strong role of gender in the response of adolescent subjects to maternal separation.