Study for the Diagnostic Screening of Paroxysmal Nocturnal Hemoglobinuria in Older Patients with Unexplained Anemia and/or Cytopenia

Ozdemir Z. N., İLHAN O., Ozet G., Falay M., Yenerel M., Tuglular T., ...Daha Fazla

CLINICAL LABORATORY, cilt.66, sa.9, ss.1709-1715, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 66 Sayı: 9
  • Basım Tarihi: 2020
  • Doi Numarası: 10.7754/clin.lab.2020.191218
  • Dergi Adı: CLINICAL LABORATORY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.1709-1715
  • Anahtar Kelimeler: paroxysmal nocturnal hemoglobinuria, older patients, multiparameter flow cytometry, consensus based clinical indications, PIG-A MUTATIONS, MYELODYSPLASTIC SYNDROMES, PNH, GUIDELINES, DISORDERS, CLONES, ADULTS
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired hematopoietic stem cell disease that may lead to weakness and death of patients, if unrecognized and untreated. Although consensus guidelines were reviewed recently for the diagnostic screening of PNH with multi-parameter flow cytometry (FCM), until now, no study has investigated the efficiency of such clinical indications in older patients.