Evaluation of pneumococcal PCR and urinary antigen detection in children

Parlakay A. Ö., CEYHAN M., ÇELİK M., ÖZSÜREKCİ Y., Karadaǧ Öncel E., Sensoy G., ...More

Clinical Laboratory, vol.59, no.11-12, pp.1409-1411, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 59 Issue: 11-12
  • Publication Date: 2013
  • Doi Number: 10.7754/clin.lab.2013.121206
  • Journal Name: Clinical Laboratory
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1409-1411
  • Keywords: Child, Pneumococcal antigen test, S. Pneumoniae
  • Dokuz Eylül University Affiliated: No


Background: The rapid detection of Streptococcus pneumoniae could assist in the management of pneumococcal infections. The Binax NOW S. pneumoniae test is a rapid immunochromatographic test for this purpose. Methods: Multiplex PCR in parapneumonic pleural effusion fluid (PPEF) and cerebrospinal fluid (CSF) with Binax NOW urinary pneumococcal antigen test (PAT) from 80 children was compared in this study. Results: PAT had a sensitivity of 36.4%, specificity of 97.3%, in CSF. PAT had a sensitivity of 50%, specificity of 81% for parapneumonic pleural effusion fluid. Conclusions: When rapid management of a serious infection is needed the Binax NOW test could be a reliable method for the exclusion of S. pneumoniae infection.