CD40 Expression In Pancreatic Cancer

ÜNEK T., ÜNEK İ. T., AYSAL AĞALAR A., SAĞOL Ö., ELLİDOKUZ H., Ertener O., ...Daha Fazla

HEPATO-GASTROENTEROLOGY, cilt.60, sa.128, ss.2085-2093, 2013 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 60 Sayı: 128
  • Basım Tarihi: 2013
  • Doi Numarası: 10.5754/hge.13421
  • Dergi Adı: HEPATO-GASTROENTEROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.2085-2093
  • Anahtar Kelimeler: CD40, Pancreatic cancer, Prognostic marker, Survival, HUMAN HEPATOCELLULAR-CARCINOMA, GROWTH-INHIBITORY ACTIVITY, FAS-MEDIATED APOPTOSIS, RENAL-CELL CARCINOMAS, CD40-CD40 LIGAND, IN-VITRO, CYTOKINE SECRETION, EPITHELIAL-CELLS, FUNCTIONAL CD40, MELANOMA-CELLS
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background: CD40, a tumor necrosis factor receptor family member is expressed in a variety of cell types. This widespread expression suggests that CD40 may play, an Important bile in normal physiology and disease pathogenesis. The objective of the current study was to investigate the expression of CD40, and its association with clinicopathological features and survival in patients with pancreatic ductal adenocarcinoma. Methodology: CD40 expression was assessed in 53 pancreatic ductal adenocarcinoma surgical specimens by immunohistochemistry, and expression Was correlated With patient clinicopathological;parameters Mid outcome.. Results: Among 58 pancreatic Cancer specimens, 040 expression wag detected in 13 specimens (24.5%), and peritumoral lymphocytes were present in 45 specimens (84.9%). Patients with CD40-positive tumors exhibited prolonged median disease-free survival (DFS) compared with patients With CD40-negative tumors (15.60 +/- 3.87 versus 10.03 +/- 1.92); however, this was not significant y(p = 0.845). Patients with peritumoral lymphocytic: reaction exhibited prolonged median DFS compared with patients without peritumoral lymphocytes (10.96 +/- 1.40 vs. 7.60 +/- 0.47); however, this was not significant (p = 0.624). Patients with peritumoral. lymphocytic reaction exhibited higher median overall,. survival compared with patients without peritumoral lymphocytes (1520 +/- 1.78 vs. 10.13 +/- 4.39); however, again this was not-Significant (p = 0 40 0); Conclusions: These results Suggest that CD40 expression on pancreatic cancer cells and peritumoral lymphocytic reaction may serve as prognostic markers.