Evaluating the incidence of pathological complete response in current international rectal cancer practice: the barriers to widespread safe deferral of surgery

Battersby N., Glasbey J. C., Neary P., Negoi I., Kamarajah S., Sgro A., ...More

COLORECTAL DISEASE, vol.20, pp.58-68, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20
  • Publication Date: 2018
  • Doi Number: 10.1111/codi.14361
  • Journal Name: COLORECTAL DISEASE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.58-68
  • Keywords: Rectal surgery, rectal cancer, pathology, radiology, neoadjuvant therapy, surgical oncology, deferral of surgery, QUALITY-OF-LIFE, PREOPERATIVE CHEMORADIOTHERAPY, NEOADJUVANT CHEMORADIOTHERAPY, TUMOR RESPONSE, CHEMORADIATION THERAPY, MERCURY EXPERIENCE, CHEMOTHERAPY, REGRESSION, SURVIVAL, TRIAL
  • Dokuz Eylül University Affiliated: No

Abstract

IntroductionThe mainstay of management for locally advanced rectal cancer is chemoradiotherapy followed by surgical resection. Following chemoradiotherapy, a complete response may be detected clinically and radiologically (cCR) prior to surgery or pathologically after surgery (pCR). We aim to report the overall complete pathological response (pCR) rate and the reliability of detecting a cCR by conventional pre-operative imaging.