Acquired factor VII deficiency in pediatric inflammatory bowel disease: Report of three cases

Çakar S., Eren G., Karapınar T. H., Ecevıt Ç. Ö., Bekem Ö.

ARAB JOURNAL OF GASTROENTEROLOGY, cilt.24, sa.4, ss.256-258, 2023 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 4
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1016/j.ajg.2023.10.002
  • Dergi Adı: ARAB JOURNAL OF GASTROENTEROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.256-258
  • Anahtar Kelimeler: Factor VII deficiency, Inflammatory bowel disease, Children
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Bleeding disorders can exacerbate gastrointestinal bleeding in inflammatory bowel disease (IBD) at the time of diagnosis or flares. Factor VII (FVII) deficiency is a life-threatening rare congenital bleeding disorder in childhood. This study describes three adolescent patients with IBD accompanied by acquired FVII deficiency. This is the first case series of patients with IBD accompanied by FVII deficiency. We hypothesized that inflammation, accelerated consumption, disease severity, and weight loss can cause decreased FVII activity in patients diagnosed with IBD. To control intestinal bleeding, we must keep in mind factor deficiencies in IBD.

Keywords: Children; Factor VII deficiency; Inflammatory bowel disease.