Acquired factor VII deficiency in pediatric inflammatory bowel disease: Report of three cases

Çakar S., Eren G., Karapınar T. H., Ecevıt Ç. Ö., Bekem Ö.

ARAB JOURNAL OF GASTROENTEROLOGY, vol.24, no.4, pp.256-258, 2023 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 4
  • Publication Date: 2023
  • Doi Number: 10.1016/j.ajg.2023.10.002
  • Journal Name: ARAB JOURNAL OF GASTROENTEROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Page Numbers: pp.256-258
  • Keywords: Factor VII deficiency, Inflammatory bowel disease, Children
  • Dokuz Eylül University Affiliated: Yes

Abstract

Bleeding disorders can exacerbate gastrointestinal bleeding in inflammatory bowel disease (IBD) at the time of diagnosis or flares. Factor VII (FVII) deficiency is a life-threatening rare congenital bleeding disorder in childhood. This study describes three adolescent patients with IBD accompanied by acquired FVII deficiency. This is the first case series of patients with IBD accompanied by FVII deficiency. We hypothesized that inflammation, accelerated consumption, disease severity, and weight loss can cause decreased FVII activity in patients diagnosed with IBD. To control intestinal bleeding, we must keep in mind factor deficiencies in IBD.

Keywords: Children; Factor VII deficiency; Inflammatory bowel disease.