Anti-apoptotic and anti-oxidant effects of grape seed proanthocyanidin extract in preventing cyclosporine A-induced nephropathy
NEPHROLOGY, vol.17, no.4, pp.372-379, 2012 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 17 Issue: 4
- Publication Date: 2012
- Doi Number: 10.1111/j.1440-1797.2012.01565.x
- Journal Name: NEPHROLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.372-379
- Keywords: apoptosis, cyclosporine, cyclosporine A-induced nephropathy, grape seed proanthocyanidin extract, nephropathy, oxidative stress
- Dokuz Eylül University Affiliated: No
Abstract
Aim: Although the pathogenesis of cyclosporine (CsA) nephropathy is not completely understood, it is attributed to oxidative damage and apoptosis. Grape seed proanthocyanidin extract (GSPE) is a molecule with antioxidant and anti-apoptotic properties. Our aim was to demonstrate the effects of GSPE in preventing CsA nephropathy.